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SERUM URIC ACID LEVEL UNDER THE CONDITIONS OF THE ALCOHOL ABSTINENCE MODELING USING THE HYDROXYPYRIDINE DERIVATIVE
Efremenko Eugene Sergeevich1, Titov Dmitry Sergeevich2, Nikonov Dmitry Alexsandrovich3
1Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health Russian Federation, Head of the Department of Biochemistry, PhD in Medical sciences, Associate Professor
2Budgetary healthcare institution Omsk regions «Narcological dispensary», assistant chief physician for medical parts
3Budgetary healthcare institution Omsk regions «Narcological dispensary», assistant chief physician for outpatient service
1Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health Russian Federation, Head of the Department of Biochemistry, PhD in Medical sciences, Associate Professor
2Budgetary healthcare institution Omsk regions «Narcological dispensary», assistant chief physician for medical parts
3Budgetary healthcare institution Omsk regions «Narcological dispensary», assistant chief physician for outpatient service
Abstract
Negative transformation of the antioxidant status of the organism in the development of alcohol dependence is associated with excessive formation of free radicals and their poor inactivation of the corresponding components of the antioxidant defense. In these conditions causes a state of oxidative stress, characteristic for various standard pathological processes and nosological forms, as well as external factors. A crucial criterion for the formation of alcohol dependence is the formation of alcohol withdrawal syndrome. To create the experimental conditions for modeling characteristics of metabolic processes in the physical alcohol dependence enables to estimate the biochemical parameters with a few other positions.
The article shows the dynamics of the serum level of uric acid in the development of ethanol withdrawal in the conditions of introduction of the derived hydroxypyridine. The data obtained testify to a possible influence of derived hy-droxypyridine for the maintenance of uric acid in the serum of the blood during the experimental simulation of the alcohol withdrawal syndrome.
Keywords: alcohol, alcohol addiction, alcohol withdrawal syndrome, alcoholism, antioxidants, free radicals, uric acid
Category: 03.00.00 Biology
Article reference:
Serum uric acid level under the conditions of the alcohol abstinence modeling using the hydroxypyridine derivative // Modern scientific researches and innovations. 2017. № 3 [Electronic journal]. URL: https://web.snauka.ru/en/issues/2017/03/79808
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