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NITROGEN CHEMICALS CONSUMPTION AS THE FACTOR OF MYOCARDIUM DYSFUNCTION IN MALE RATS
Zadnipryany Igor Vladimirovich1, Tretiakova Olga Stepanova2, Sataieva Tatiana Pavlovna3
1Medical Academy of Crimea Federal University, MD, Professor, Department of Human Anatomy
2Medical Academy of Crimea Federal University, MD, Professor, Doctor of Medical Science, Head of department of Public Health
3Medical Academy of Crimea Federal University, PhD, assistant of Medical Biology Department
1Medical Academy of Crimea Federal University, MD, Professor, Department of Human Anatomy
2Medical Academy of Crimea Federal University, MD, Professor, Doctor of Medical Science, Head of department of Public Health
3Medical Academy of Crimea Federal University, PhD, assistant of Medical Biology Department
Abstract
In this article we represented the morphometric parameters of the myocardium of male rats during development of hypoxia induced by sodium nitrite NaNO2. It was found out that chronic intake of nitrogen-containing xenobiotics in the body and has a strong toxic effect on the myocardium of male rats, which is manifested in the form of ischemic and hypoxic damage contractile cardiomyocytes and endothelial cells, with subsequent their death. The main morphological features of nitrite myocardial damage were presented in form of mixed dystrophy and contractile cardiac edema, lysis of myofibrils, rigor complexes. Also, there was a significant increase of arterioles diameter and increased amount collagen fibers in the interstitium. We revealed signs of structural violations which are predictors of myocardial dysfunction.
Keywords: cardiomyocytes, hemic hypoxia, morphometry, myocardium, rats
Category: 14.00.00 Medicine
Article reference:
Nitrogen chemicals consumption as the factor of myocardium dysfunction in male rats // Modern scientific researches and innovations. 2015. № 2. P. 4 [Electronic journal]. URL: https://web.snauka.ru/en/issues/2015/02/46993
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